COLLECTIVE MADNESS


“Soft despotism is a term coined by Alexis de Tocqueville describing the state into which a country overrun by "a network of small complicated rules" might degrade. Soft despotism is different from despotism (also called 'hard despotism') in the sense that it is not obvious to the people."

Tuesday, May 01, 2007

Rump presentation is important for libido.


Hope for sex-boost slimming pill BBC

Around 40% of women are said to experience low libido at some point
Scientists are developing a pill which could boost women's libido and reduce their appetite.

The hormone-releasing pill has so far only been given to female monkeys and shrews who displayed more mating behaviour and ate less.

The team from the Medical Research Council's Human Reproduction Unit in Edinburgh believe a human version could be available within a decade.

But a psychologist said low-libido was usually caused by relationship issues.

Up to 40% of women are thought to experience a lack of sex drive at some point in their lives.

A third of women constantly worry about the way their body looks, a survey last year suggested.

'Rump presentation'


The Edinburgh team, led by Professor Robert Millar, have been looking at the properties Type 2 Gonadotrophin-releasing hormone.

When it was given to monkeys, they displayed mating behaviour such as tongue-flicking and eyebrow-raising to the males, while female shrews displayed their feelings via "rump presentation and tail wagging".


'When couples come to me and they are not having sex, the last thing they want to do is examine their relationship'
Lesley Perman-Kerr, psychologist

But the animals also ate around a third less food than they normally would.

Professor Millar hopes to achieve a similar rise in libido and fall in appetite in a pill for women.

He told the Scotland on Sunday newspaper: "This hormone is distributed in the brain in areas that we suspect affect reproductive behaviour.

"It is considered a major pharmaceutical endeavour to address the area of libido.

"So the next stage is to produce a drug that simulates the actions of this hormone.

"It is most likely that we will do it in partnership with a pharmaceutical firm. It could be available to women within the next 10 years."

He said it may also be possible to develop a pill which worked for men, but he has so far not carried out any tests on male animals.

But psychologist Lesley Perman-Kerr said relationship problems usually had a psychological, rather than a biological, basis.

"Some women have problems specific to libido."

"But often if they go off sex, it's more to do with their relationship that their level of libido.

"When couples come to me and they are not having sex, the last thing they want to do is examine their relationship.

"They want to believe that it's nothing to do with their relationship."


25 comments:

  1. I wasso excited by the booty call, forgot to enable the comments.

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  2. Man o man ..out of the can fo a day and I see the girl of my dreams.

    Antake it to the bank

    HogZill-willa-do-fine-behind.

    I like big butts and I can not lie
    You other brothers can't deny
    That when a girl walks in with an itty bitty waist
    And a round thing in your face
    You get sprung, wanna pull out your tough
    'Cause you notice that butt was stuffed
    Deep in the jeans she's wearing
    I'm hooked and I can't stop staring
    Oh baby, I wanna get wit'cha
    And take your picture
    My homeboys tried to warn me
    But with that butt you got makes me feel so horny
    Ooh, Rump-o'-smooth-skin
    You say you wanna get in my Benz?
    Well, use me, use me
    'Cause you ain't that average groupy
    I've seen them dancin'
    The hell with romancin'
    She's sweat, wet,
    Got it goin' like a turbo 'Vette
    I'm tired of magazines
    Sayin' flat butts are the thing
    Take the average black man and ask him that
    She gotta pack much back
    So, fellas! (Yeah!) Fellas! (Yeah!)
    Has your girlfriend got the butt? (Hell yeah!)
    Tell 'em to shake it! (Shake it!) Shake it! (Shake it!)
    Shake that healthy butt!
    Baby got back!

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  3. So your girlfriend rolls a Honda, playin' workout tapes by Fonda
    But Fonda ain't got a motor in the back of her Honda
    My anaconda don't want none
    Unless you've got buns, hun

    You can do side bends or sit-ups,
    But please don't lose that butt
    Some brothers wanna play that "hard" role
    And tell you that the butt ain't gold
    So they toss it and leave it
    And I pull up quick to retrieve it
    So Cosmo says you're fat
    Well I ain't down with that!
    'Cause your waist is small and your curves are kickin'
    And I'm thinkin' bout stickin'
    To the beanpole dames in the magazines:
    You ain't it, Miss Thing!
    Give me a sista, I can't resist her
    Red beans and rice didn't miss her
    Some knucklehead tried to dis
    'Cause his girls are on my list
    He had game but he chose to hit 'em
    And I pull up quick to get wit 'em
    So ladies, if the butt is round,
    And you want a triple X throw down,
    Dial 1-900-MIXALOT
    And kick them nasty thoughts
    Baby got back!

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  4. Is that your Main Squeeze,
    Hogzillatater?

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  5. "It is considered a major pharmaceutical endeavour to address the area of libido."

    Conversely, weight loss is associated with an increase in libido; and it (weight loss) is the pharmaceutical golden calf because being overweight or obese is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease (and even cancer).

    If lifestyle intervention fails;
    two agents with significant effects on weight loss.

    First, exenatide (Byetta), an incretin mimetic which is a synthetic form of the protein GLP-1.

    Second, awaiting approval, rimonabant (Acomplia) is an endocannabinoid receptor inhibitor.

    Paradigm shift -
    A decade ago, adipose tissue was viewed as a passive storage area of triglycerides but is now viewed as an active inflammatory organ producing 'adipokines.'

    Of course, i could be BSing all of the above.

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  6. Elijah,
    Great post! I would just add this.

    Transfer of probiotic-treated DCs conferred protection against 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced colitis. Protection was associated with a reduction of inflammatory scores and colonic expression of pro-inflammatory genes, while a high local expression of the immunoregulatory enzyme indolamine 2, 3 1dioxgenase (IDO) was observed. The preventive effect of probiotic-pulsed DCs required not only MyD88-, TLR2- and NOD2-dependent signaling but also the induction of CD4+ CD25+ regulatory cells in an IL-10-independent pathway.
    This leads us to conclude:
    Altogether, these results suggest that selected probiotics can stimulate DC regulatory functions by targeting specific pattern-recognition receptors and pathways. The results not only emphasize the role of DCs in probiotic immune interactions, but indicate a possible role in immune-intervention therapy for IBD.

    Some ongoing research is still need.
    Thanks for bring up this most informative topic

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  7. yeah dudes WTF is you guys trying to shovel.
    back on the line we'd done shivved yo ass try'n ta talk smoove with tricknology.

    HogzillaTater feeds baby!

    I'm a streamroller baby, I'm bound ta roll all ova you....
    I be into you to SquirtEyeTater you be talk'n no jive then..

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  8. Yeah, but if taken by the back door, is all this science really going to save our metrosexual civilization?

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  9. elijah..what are your thoughts on this idea:

    Glycosaminoglycan Interactions in Murine Gammaherpesvirus-68 Infection
    Glycosaminoglycans (GAGs) commonly participate in herpesvirus entry. They are thought to provide a reversible attachment to cells that promotes subsequent receptor binding. Murine gamma-herpesvirus-68 (MHV-68) infection of fibroblasts and epithelial cells is highly GAG-dependent. This is a function of the viral gp150, in that gp150-deficient mutants are much less GAG-dependent than wild-type. Here we show that the major MHV-68 GAG-binding protein is not gp150 but gp70, a product of ORF4. Surprisingly, ORF4-deficient MHV-68 showed normal cell binding and was more sensitive than wild-type to inhibition by soluble heparin rather than less. Thus, the most obvious viral GAG interaction made little direct contribution to infection. Indeed, a large fraction of the virion gp70 had its GAG-binding domain removed by post-translational cleavage. ORF4 may therefore act mainly to absorb soluble GAGs and prevent them from engaging gp150 prematurely. In contrast to gp70, gp150 bound poorly to GAGs, implying that it provides little in the way of adhesion. We hypothesize that it acts instead as a GAG-sensitive switch that selectively activates MHV-68 entry at cell surfaces.

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  10. Mətušélaḥ

    Ain't nut'n sav'n this country from be'in overrun with girly men.

    ReplyDelete
  11. Betcha that room under the dome is nice

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  12. doug,

    those folks WTSHTF (when the shit hits the fan) will have targets on their backs.

    Top Hamas official: Kill all Americans

    Sheik Ahmad Bahr, acting Speaker of the Palestinian Legislative Council, declared during a Friday sermon at a Sudan mosque that America and Israel will be annihilated and called upon Allah to kill Jews and Americans "to the very Last One". Following are excerpts from the sermon that took place last month, courtesy of MEMRI.

    Ahmad Bahr began: "You will be victorious" on the face of this planet. You are the masters of the world on the face of this planet. Yes, [the Koran says that] "you will be victorious," but only "if you are believers." Allah willing, "you will be victorious," while America and Israel will be annihilated. I guarantee you that the power of belief and faith is greater than the power of America and Israel. They are cowards, who are eager for life, while we are eager for death for the sake of Allah. That is why America's nose was rubbed in the mud in Iraq, in Afghanistan, in Somalia, and everywhere.

    Bahr continued and said that America will be annihilated, while Islam will remain. The Muslims "will be victorious, if you are believers." Oh Muslims, I guarantee you that the power of Allah is greater than America, by whom many are blinded today. Some people are blinded by the power of America. We say to them that with the might of Allah, with the might of His Messenger, and with the power of Allah, we are stronger than America and Israel.

    The Hamas spokesperson concluded with a prayer, saying: "Oh Allah, vanquish the Jews and their supporters. Oh Allah, count their numbers, and kill them all, down to the very last one. Oh Allah, show them a day of darkness. Oh Allah, who sent down His Book, the mover of the clouds, who defeated the enemies of the Prophet defeat the Jews and the Americans, and bring us victory over them."

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  13. Hogzilla,

    That's really a matter of personal psychological bias.

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  14. Goodness, didn't know we had so many basic research scientists on this site.

    Or is it cutting and pasting; i am great at that i've been told.

    The biological sciences were of great interest at one time and i still read the literature.

    Habu and Hogzillatater, expertise in inflammation and molecular biology i see, let's see if it extends to the clinical setting.

    Lots of questions then -

    1) Is metabolic syndrome actually a syndrome, if so, what is the etiology?

    2) What are your thoughts on the 'common soil' hypothesis?

    3) Does plaque regression as measured via IVUS equate to plaque stability?

    4) On a different note, what is the true capability of AESA radar?

    i have far to go and much to learn, teach me.

    ReplyDelete
  15. elijah,
    One at a time...

    Both genetic and environmental factors are involved in the etiology of obesity and the associated lipid disturbances. We determined whether acquired obesity is associated with changes in global serum lipid profiles independent of genetic factors in young adult monozygotic (MZ) twins. 14 healthy MZ pairs discordant for obesity (10 to 25 kg weight difference) and ten weight concordant control pairs aged 24–27 years were identified from a large population-based study. Insulin sensitivity was assessed by the euglycemic clamp technique, and body composition by DEXA (% body fat) and by MRI (subcutaneous and intra-abdominal fat). Global characterization of lipid molecular species in serum was performed by a lipidomics strategy using liquid chromatography coupled to mass spectrometry. Obesity, independent of genetic influences, was primarily related to increases in lysophosphatidylcholines, lipids found in proinflammatory and proatherogenic conditions and to decreases in ether phospholipids, which are known to have antioxidant properties. These lipid changes were associated with insulin resistance, a pathogonomic characteristic of acquired obesity in these young adult twins. Our results show that obesity, already in its early stages and independent of genetic influences, is associated with deleterious alterations in the lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance.

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  16. 'Common soil' is soil that has been worked for generations with a moldboard plow or other suitable instrument, by 'common people', usually for a pittance of 'common money'. i.e. money received in return for a life satisfying 'common need' that is, nutrition.

    An illustration of 'uncommon soil' can be found in Doug's post above under "Feinstein's Digs", soil which has never been worked by anyone, common or no, and sells for a king's ransom in return for satisfying any of many of life's needless cravings, in order to give the buyer the illusion of meaning.

    That's the meaning of 'common soil'.

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  17. It has also been said in the great traditions that if you sell you soul for uncommon soil you soil for soul even if you gain the whole sordid world. And become dirty in the process.

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  18. Did I read that Feinstein uses almost slave labor in some asian county to pay for the digs, or was that some other california politician? Overseas labor being exempt from the recent wage increases here? That couldn't possibly be, could it?

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  19. Well hot dam habu, i am feeling randy tonight (blame the crown royal), let's talk about the metabolic realm.

    Etiology of obesity - genetic and environmental factors are involved in the etiology.

    Sorry, i believe the human genome has not changed substantially over the last two decades, whereas the prevalence of diabetes (type 2) as driven by the prevalence of obesity has increased substantially. Therefore, the genetic argument as it relates to obesity is lacking (i.e. - we are eating ourselves to death).

    Euglycemic clamp technique - what does that tell us about beta cell dysfunction? How good does glucophage and the TZDs work if there is no production of insulin by the beta cells (although the alpha cells are important as well-glucagon driving HGP).

    "These lipid changes were associated with insulin resistance"
    ...as the level of adiposity increases so too the degree of insulin resistance - obesity is also associated with beta cell dysfunction (glucotoxicity and lipotoxicity)

    "lipid metabolism known to facilitate atherogenesis, inflammation and insulin resistance."

    Bravo brother - obesity, inflammation, and insulin resistance are all proposed as the
    etiological impetus of the metabolic syndrome

    And comparing metabolic syndrome and diabetes, are they the same basically? Aren't the components of metabolic syndrome the diabetic ABCs?

    Get that BMI to 25 or less.
    ..................................

    from the metabolic realm bobalharb - common soil relates to the hypothesis that inflammation is the common antecedent for Metsyn, Type 2 diabetes, and atherosclerosis

    ...................................
    And all of u thought i was a one trick pony

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  20. Breasts Not Bombs, Dicks, not Death

    Highlights on this page:

    On cue, the Bay Area's most notorious nude anarchist showed up as well -- fortunately, this time he had neglected to inflate his scrotum to gargantuan proportions as he had done the last time I met him. Only some minor swelling remained.

    If there's anything better than revolutionary nudity, it's revolutionary transgendered nudity. Most of the participants were readily identifiable as either male or female, but this bearded, breasted, tattooed protester dared to challenge our outmoded gender labels.

    The main drawback to repeatedly inflating your scrotum is that it tends to make your wee-wee look smaller and smaller.

    The First Dysfunctional Family

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  21. Man, How I miss Beserkley.

    Hell, now I could BE Miss Beserkley.

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